To Whom It May Concern

To Whom It May Concern,

Anyone familiar with biology will recognize that biological systems and phenomena are often very complex. The more one studies biology in detail, the more one becomes aware of its intrinsic complexity. Molecular biologists will certainly agree with this. The level of sophistication increases even more as biological systems become more vulnerable, especially when interactions with other biological systems create dynamics that are vital for their maintenance. This is why the level of biological complexity within entire ecosystems culminates at a point that is difficult for humans to fully comprehend.

But what is the biological significance of this complexity? The complexity of biological phenomena often resembles a real spiderweb, where, much like a busy traffic intersection, many paths cross and change direction. By alternating steps in one direction with steps in another, often even opposite direction, it becomes possible to continuously adjust, modulate, and refine biological processes and reactions. This not only leads to a high degree of sophistication, and therefore vulnerability, in vital biological phenomena but also to a high degree of versatility and diversity. It is precisely this variation that is crucial for ensuring that complex, and hence more fragile, biological systems can thrive, even in the face of environmental threats. This is especially true when these threats come from biological agents that have evolved to sustain themselves with a much lower degree of biological complexity and vulnerability. It is precisely the spectrum of variations generated by the complexity of biological processes themselves and the myriads of mutual interactions with other systems that creates a wide range of possibilities for these vulnerable systems to adapt purposefully to threatening environmental factors. This adaptation occurs through the natural selection of the random’ variant(s)’ whose phenotypic complexity confers a competitive fitness advantage in hostile circumstances.

If the responsiveness of autonomously living biological organisms consisted only of a simple black-and-white reaction, then the confrontation with an unfavorable environmental factor would either result in a large-scale extinction of the species or in its widespread survival, ultimately leading to other factors that could also threaten the species' survival (e.g., depletion of food resources or other detrimental consequences of overpopulation). However, when the adaptability of an entire ecosystem—such as an animal population interacting with a pathogenic germ—is undermined by an unnatural, ill-adapted large-scale intervention, the population's capacity to effectively control the pathogen is at risk of gradually declining. It is not difficult to understand that this is particularly true when the 'hostile' environmental threat comes from a viable biological agent that, due to its primitive reproduction strategy, is much less vulnerable because it only needs to survive and reproduce within the safe environment of a host cell, such as a virus. In this way, the roles are reversed, and the more evolved and vulnerable organism gradually loses its ability to adapt, giving the more primitive adversary a strategic advantage.

For those who have followed my insights and predictions regarding the endpoint of the ongoing immune escape pandemic, this precisely explains how mass vaccination against SARS-CoV-2 during the pandemic has actually benefited the virus's adaptation, rather than that of the Covid 19 (C19)-vaccinated population. The systematic breakthrough infections in C19-vaccinated individuals have led to a collective reduction in the immune system’s adaptability (i.e., adaptive immunity) of highly C-19 vaccinated populations, thereby improving the survival chances of the less vulnerable virus. The adaptive capacity of highly C-19 vaccinated populations has eventually been limited to protection against virulence through polyreactive non-neutralizing antibodies (PNNAbs), a protection that we know does not evolve further and cannot prevent the virus from spreading (and thus adapting). Because the evolutionary dynamics of the virus, fueled by nonpharmaceutical infection-prevention measures and mass vaccination, have caused the antigenic stimulus that maintained the concentration of these antibodies to disappear, it seems more than plausible that this human-induced viral dynamics will ultimately pull the emergency brake to prevent the extinction of highly C-19 vaccinated populations. Indeed, if the collective immunological adaptability is restricted to the extent that it prevents the development of herd immunity, then only a higher degree of adaptability of the virus can offer a solution. The evidence of the virus's increasing adaptability has become clearly visible for quite some time, especially since the emergence of Omicron. At the current stage of this immune escape pandemic, the virus's adaptability is only further stimulated by the increasingly reduced capacity of highly C-19 vaccinated populations to control viral spread and replication.

There is no doubt that under the significant but 'misplaced' immune pressure exerted by highly C-19 vaccinated populations, the virus’s unchecked adaptability can only escalate. This escalation could ultimately give the unvaccinated part of these populations the opportunity to establish herd immunity through epigenetic reprogramming (‘adaptation’) of their innate immune cells, thereby breaking the cycle of ongoing immune escape by the virus.

It is also logical that when the robust adaptability of vulnerable biological entities is disrupted, it may take some time before their stability is collectively undermined and the system collapses under hostile pressure. Nevertheless, it’s clear that when small cracks in a dam’s wall begin to expand into larger fissures, the system’s stability deteriorates very rapidly, and thus the metastable system can suddenly collapse, much like a thunderbolt striking out of a clear sky. Such entities will therefore likely be caught off guard...

Together with those who criticize the timeline I predicted for the termination of the C-19 immune escape pandemic, I am amazed by the remarkable resilience of the complex biological system involved. This can only mean that the ability of our mammalian immune system to collectively adapt to far less biologically complex pathogens is truly spectacular and shows a resilience of unprecedented magnitude. Such remarkable resilience can only be destroyed by large-scale, unnatural and thoughtless immune interventions, but not in a way that nature has not provided a contingency plan to ensure the survival of our species.

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