The complete article was published on the Alliance for Natural Health website on August 23rd 2023.

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Summary of the key messages:

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Immune refocusing is the key to immune escape and collateral non-SARS-CoV-2 disease

• Immune refocusing (IR) to more conserved, immune subdominant spike-associated domainselicits subneutralizing antibodies that promote large-scale immune escape and mature into IgG4s that react with self- or altered self epitopes on the surface of healthy or pathologically transformed host cells.
• Pathogenic IgG4 Abs link immune escape and vaccine breakthrough infections (VBTIs) toincreased incidence of autoimmune diseases and early-onset cancers.
• Immune pathology (incl. cancer) results from IR-enabling VBTI or IR-enabling vaccination (mRNA vaccination).

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High IgG4 Ab titers combined with exposure to highly infectious variants link immune selection pressure on viral virulence to generalized immune suppression

• High titers of IgG4 Abs no longer enable immune refocusing upon exposure to highly infectious SARS-CoV-2 variants and prevent production of (polyreactive) non-neutralizing antibodies (Abs). 
• When these Abs collectively decline below an optimal threshold, the virus will likely break through their virulence-inhibiting capacity and unleash a major wave of severe Covid-19 disease.

Immune pathology is triggered byimmune refocusing and therefore caused by vaccine breakthrough infections(VBTI) or mRNA vaccination

• The likelihood for Covid-19 vaccinees to contract immune pathology or cancer, or to suffer from resurgence of chronic infection following VBTI with Omicron descendants in highly C-19 vaccinated populations is not primarily determined by genetic predisposition, environmental factors or demographic characteristics but by the amount of time elapsed since the first occurrence of immune refocusing.
• The type of pathology and the type of organ/ tissue affected depends on the specificity of the pathogenic anti-spike IgG4 Abs.

There is a calm just now; the calm before the storm

• Enhanced rate of cancers, autoimmune disorders or exacerbations of other, chronic infections in the context of low Covid-19 morbidity and mortality rates are currently the only and last clinical alert left to warn highly C-19 vaccinated countries about a dramatic and imminent viral immune escape event. 
• However, as the origin of the above-described side effects and excess deaths in highly C-19 vaccinated populations is currently not debatable and as their nature is not considered by scientists and health authorities to reflect dangerous immune escape, I keep shouting that society in highly Covid-19 vaccinated countries will be caught off guard!

High IgG4 Abs are correlates of immune escape

• Measuring IgG4 Ab titers in the blood of asymptomatic C-19 vaccinees, possibly complemented by measuring infectious shedding in mucosal swabs (via SARS-CoV-2 Ag test or RT-PCR), could be a good proxy for investigating irreversible immune escape (i.e., following IR-enabling VBTI).
• I postulate that a high prevalence of high titers of IgG4 Abs in a highly C-19 vaccinated population is to be considered a poor prognostic sign for the outcome of this SARS-CoV-2 (immune escape) pandemic.

Who’s at risk? How can people at risk protect themselves?

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download article as a PDF 

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